Synthesis & Antidepressant Activity Of Tetrahydro Benzothiophene Derivatives.

Abstract

The synthesis, structure and biological activity of benzothiophene has been long focus of research interests in the field of Medicinal Chemistry. Benzothiophene nucleus has been established as the potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics. A series of tetrahydro benzothiophene derivatives was synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate was synthesized via a multicomponent condensation between sulphur, cyclohexanone and ethylcyanoacetate adopting Gewald Reaction. The Compound 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate was Reacted into respective substituted chloroacetanilide. The synthesized compound were further processed into the final compounds i.e.2-{[Substituted-phenylcarbamoyl)-methyl]-amino}-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester. All synthesized compound were characterized by IR, H1-NMR and elemental Analysis. All the newly synthesized derivatives were screened for Antidepressant activity using Sertraline HCL  as a standard.