Allergy, is a clinical expression of soluble factors like IgE, histamine or eosinophils found in serum or plasma of such patients. The products that are responsible for allergy are called as Allergens. Allergens normally induce IgE production which leads to type 1 hypersensitivity response on subsequent exposure to the same allergen. The target organs are mostly nose, lung, skin and gastrointestinal tract. Atopy is also considered as a triad of Atopic dermatitis, allergic rhinitis and bronchial asthma. Raised serum IgE and AEC are proven indicators of allergic phenomenon. Various studies show relationship between serum Immunoglobulin E level and total eosinophil count in population suffering from allergic diseases. Serum total Immunoglobulin E, total eosinophil count and specific IgE are all helpful for the diagnosis and treatment of allergic diseases. Objectives: 1.To Evaluate Serum Total IgE level in Children with allergic diseases.2. To Evaluate Absolute Eosinophil Count (AEC) in children with allergic diseases.3. To Correlate Serum Total Immunoglobulin E Level and Absolute Eosinophil Count (AEC) with allergic diseases. Methodology: Cross sectional study with 100 children in the age group 2-12 years with nasopharyngeal allergies (like bronchial asthma and atopic rhinitis) and skin allergies (like atopic dermatitis, urticaria) ,eye allergies were enrolled and serum IgE levels and AEC levels was done. Results: In present study Absolute eosinophil count was raised in 58% of cases Serum IgE was raised in 54% of cases. In present study, of 58% cases with raised Absolute eosinophil count 81% (47 cases) showed raised serum IgE levels. Conclusion: Absolute eosinophil count and serum Total IgE has been considered as a significant marker of allergic state and can be used as a marker of allergic response in atopic individuals. Raised serum IgE and AEC are more in nasobronchial allergy as compare to other systemic allergies. The elevated level of serum Total IgE and Absolute Eosinophil Count both shows Significant Correlation thus can be considered as a dependable laboratory investigation in diagnosing and categorizing allergic diseases.
Cezmi A Akdis , Scott H. Sicherer. Allergy and the immunologic basis of atopic disease. In: Nelson Textbook of Pediatrics. 21sted Philadelphia: ELSEVIER: Chapter 166 pg1170-74.
Repaport HG. Clemens von Pirquetandalerty. Anu Allergy .1973, 31:467-75. (ISI Medline)
Gustafsson D, Sjoberg O, Foucard T et al. Development of allergies and asthma in infants and young children with atopic dermatitis: A prospective follow-up up to 7 years of age. Allergy 2000; 55: 240-245.
Prasad R, Kumar R, Allergy Situation in India: what is being done? Indian J Chest dis allied Sci. 2013; 55:7-8.
S. Manohar and R. Selvakumaran S. Manohar et al Estimation of serum immunoglobulin E (IgE) level in allergic asthma and allergic rhinitis patients before and after treatment
Euro. J. Exp. Bio., 2012, 2 (6): 2199-2205
V.S. Chowdary, E.C. Vinaykumar, J.J. Rao, Ratna Rao, K. Ram Babu A Study on Serum IgE and Eosinophils in Respiratory Allergy Patients Indian J Allergy Asthma Immunol 2003; 17(1) : 21-24
Piyush Gupta, PSN Menon .Immunity, immune disorders, and Allergy. In PG Textbook of Pediatrics. 2nd ed New Delhi: Jaypee 2018. Chapter 4.6 pg212.
Ravindra S, Nilesh A et al .Study of eosinophil count in nasal and blood smear in allergic respiratory diseases. MVP Journal of medical sciences. January 2016.vol 3(1), 44-51.
G S Chaudhary, Avinash Kumar, Madhurmay Shashtri, Vidya Chaudhary. Comparison of total serum immunoglobulin E and absolute eosinophil count levels among asthmatic and non-asthmatic children. Indian J Child Health. 2017, 4(3): 345-347.
Midyat L. et al .Correlation of serum specific IgE and skin prick test in children with respiratory allergy. Yeditepe medical journal 2011, 5(19):421-428.
Mohammad Gharagozlou ,Vahid rastegari , Masoud Movahedi ,Mostafa moin et al .Total serum IgE Levels and skin test in children with respiratory allergy .Tanaffos (2005) 4(15) , 27-31.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright (c) 2020 Array