To Study the Polymorphic Chromosomal Variants & Male Infertility
Keywords:
Male infertility, Polymorphic Chromosomal variants, Karyotyping, Azoospermia, OligozoospermiaAbstract
Objectives: To find out the frequency and types of polymorphic chromosomal variants and its impact in male infertility. Design: A case control study was carried on peripheral blood lymphocytes with standard G-banding technique in infertile males versus control fertile males. Patient(s): 180 infertile men and 60 control fertile men. Intervention(s): Semen analysis, Karyotyping by G-banding technique. Main Outcome measure(s): Polymorphic chromosome variants in infertile males prior to the use of assisted reproduction technique like ICSI versus control fertile males. Result(s): To indentify these chromosomal variants, the karyotyping of 180 infertile men including; 43 azoospermics and 137 oligozoospermics (106 severe oligozoospermics) were carried on peripheral blood lymphocytes with standard G-banding technique. In this study, the occurrence of polymorphic variants was high (31.1%) in infertile men, but remained similar (35%) in fertile men of control group (P>0.05). Conclusion(s): Since the genetic risk to the next generation, the occurrence of Polymorphic chromosomal variants with other chromosomal abnormalities among these infertile men strongly suggests the genetic testing and counseling of infertile couples prior to the use of assisted reproduction technique and it should be mandatory in all infertility clinics.
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