Choroidal Melanoma : Case Report
Keywords:
Slit lamp bio-microscopy (SLBE), Normal size reactive to light (NSRTL), Choroidal melanomaAbstract
A 61 year old male was referred to the ocular oncology clinic with an one month history of diminision of vision in the right eye. Patient was apparently alright 1 month back, when he developed diminision of vision; it was sudden in onset, gradually progressive and painless. On examination vision in right eye was 6/60 and left eye 6/36. On SLBE anterior segment for the above complaints. On B-scan it showed convex polypoidal mass in right eye. Colour doppler revealed vascularity in mass. MRI was done to confirm the findings.
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References
Duke-Elder S, Perkins ES. Vol. 9. London: Henry Kimpton; 1966. Diseases of uveal tract in System of Ophthalmology; p. 843.
Garcia- Valenzuela E et al, Choroidal Melanoma, Medscape, May 2011.
Denniston AKO, Murray PI; Oxford Handbook of Opthalmology (OUP), 2009
Histopathologic Characteristics of uveal melanomas in eyes enucleated from the Collaborative Ocular Melanoma Study. COMS report no. 6. Am J ophthalmol. Jun 1998; 125(6): 745-66.
McLean IW, Foster WD, Zimmerman LE, Gamel JW: Modifications of Callender’s classification of uveal melanoma at the Armed Forces Institute of Pathology. Am J Ophthalmol 96: 502-509, 1983.
Mortality in patients with small choroidal melanoma. COMS report no. 4. The Collaborative Ocular Melanoma Study Group. Arch ophthalmol. Jul 1997; 115(7): 886-93.
Orlando R, Lumachi F; Late liver metastases of choroidal melanoma detected by laparoscopy. In Vivo. 2008 Nov- Dec; 22(6): 807-9.
Choroidal melanoma metastasizing to maxillofacial bones. World J Surg Oncol. 2007 Mar 8; 5: 30.
Aalto Y, Eriksson L, Seregard S, Larsson O, Knuutila S. Concomitant loss of chromosome 3 and whole arm losses and gains of chromosome 1, 6, or 8 in metastasizing primary uveal melanoma. Invest Ophthalmol Vis Sci. 2001; 42:313-7.
Kilic E, Naus NC, Van Gils W, Klaver CC, van Til ME, Verbiest MM, et al. Concurrent loss of chromosome arm 1p and chromosome 3 predicts a decreased disease-free survival in uveal melanoma patients. Invest Ophthalmol Vis Sci. 2005; 46: 2253-7.
Hausler T, Stang A, Anastassiou G, Jockel KH, Mrzyk S, Horsthemke B, et al. Loss of heterozygosity of 1p in uveal melanomas with monosomy 3. Int J Cancer. 2005; 116:909-13.
Prescher G, Bornfeld N, Hirche H, Horsthemke B, Jockel KH, Becher R. Prognostic implications of monosomy 3 in uveal melanoma. Lancet. 1996;347: 1222-5.
Sisley K, Rennie IG, Parsons MA, Jacques R, Hammond D, Bell SM, et al. Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis. Genes Chromosomes Cancer. 1997;19: 22-8.
White VA, Chambers JD, Courtright PD, Chang WY, Horsman DE. Correlation of cytogenetic abnormalities with the outcome of patients with uveal melanoma. Cancer. 1998; 83: 354-9.
Ganley JP, Comstock GW. Benign nevi and malignant melanomas of the choriid. Am J Ophthalmol. 1973;76: 19-25.
Lee JA, Storer BE. Excess of malignant melanomas in woman in the British Isles. Lancet. 1980;2: 1337-9.
Lee JA, Storer BE. Malignant melanoma female/male deat ratios. Lancet. 1981;1: 1419.
Gallagher RP, Elwood JM, Rootman J, Spinelli JJ, Hill GB, Threlfall WJ,et al. Risk factors for ocularmelanoma: Western Canada Melanoma Study. J Natl cancer Inst. 1985; 74:775-8.
Holly EA, Aston DA, Char DH, Kristiansan JJ, Ahn DK. Uveal melanoma in relation to ultraviolet light exposure and host factors. Cancer Res. 1990; 50: 5773-7.
Hawkins BS. Collaborative Ocular Melanoma Study Group. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24. Am J Ophthalmol. 2004;138: 936-51.
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