Effect of Diabecon a Multiherbal Formulation On Serum Glucose Level In Alloxan Induced Diabetic Rats

Abstract

Background: Diabetes mellitus is a group of metabolic disorders characterised by hyperglycemia resulting from defects in insulin secretion, action and both. Though different types of oral hypoglycemic agents are available along with insulin for the treatment of Diabetes Mellitus, there is growing interest in herbal remedies, due to side effects associated with these therapeutic agents. Because of their perceived effectiveness, minimal side effects in clinical experience and relatively low costs, herbal drugs are prescribed widely. Diabecon (commercial name of a polyherbal drug) is a mixture of various extracts derived from Indian indigenous herbs commonly used against diabetes. The objective of our study is to study the effects of diabecon a multiherbal preparation on serum glucose level in alloxan induced diabetic rats. Methodology: Alloxan induced diabetic rats of either sex were divided into two groups (Group A and Group B), each group consisting of six animals.  Group A was control group and Group B was test group. Group A animals were treated with distilled water while group B animals were treated with Diabecon (1 mg/kg/day, single daily dose) for 28 days. Blood samples were collected after 1, 3 and 6 hr after last dose of the test drug on 28^th day and serum glucose level was estimated in control and diabecon treated group. Paired and Unpaired t test were used for the analysis of the result. Result: In diabetic rats, diabecon produced significant hypoglycemic effect after 28days treatment. Conclusion: In our study we found that Diabecon has significant serum glucose lowering effect in alloxan induced diabetic rats.