Severe Vitamin B12 Deficiency Leading to Cerebral Atrophy
Keywords:
Vitamin B12 deficiency, Cerebral atrophyAbstract
Vitamin B deficiency is rare disorder in infants and is generally due to vitamin B12 (cobalamin) deficiency in mother which is usually secondary to pernicious anemia, strict vegetarian diet and malnourishment. Neurological symptoms of vitamin B12 deficiency in infants include irritability, failure to thrive, hypotonia and development regression/ delay. We report a 9-month old infant with insidious developmental regression hypotonic macrocytic anemia and generalized cerebral atrophy on CT scan brain which is markedly improved after vitamin B12 administration.
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Erasmo Barbante Casella, Marcelo Valente Jessie Medeiros de Navarro, Fernando Kok
Vitamin B12 deficiency in infancy as a cause of developmental regression. Brain and
development27(2005)592-594.
Mongale PT, Tauro GP, Infantile megaloblastosis secondary to maternal Vitamin B12 deficiency. Clin Lab haemol 1997;19:23-5
Emery ES, Homans AC, Colleti RB. Vitamin B12 deficiency: a cause of abnormal deve apent in infants. Pediatrics 1997:99:255-23
Allen LH: Vitamin B12 metabolism and status during pregnancy, lactation and infancy dv.ExpMed Biol 1994;352:173-186.
Dror DK, Allen LH. Effect of Vitamin B12 deficiency on neurodevelopment in infants:
current knowledge and possible mechanism. Nutr Rev 2008;66:250-255.
Jhaday M, Webb JK, Vaishnava S Baker SJ. Vitamin B12 deficiency in Indian Infants A
clinical syndrome. Lancet 1962;2903-907.
Von Schenck U, Bender-Gote C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B12 deficiency in infancy. Archdis Child 1997;77:137-139.
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