Airway Antioxidant Capacity In Adenosine-Signalling Pulmonary Fibrosis In Lung Disease Patient
Keywords:
Adenosine deaminase, Lung fibrosis, Total antioxidant capacity, adenosine receptorAbstract
Background: Pulmonary fibrosis is a common feature of numerous lung disorders, including interstitial lung diseases, asthma and chronic obstructive pulmonary disease. Adenosine is a purine signalling nucleoside that is generated in excess during cellular stress and damage. Objective: the goal of this study was to explore the impact of endogenous adenosine elevations on pulmonary fibrosis and to compare ADA activity with total antioxidant capacity in lung disease patients. Methodology: in the present study 100 healthy non smokers were served as controls and 60 patients with lung fibrosis were included. Their base line clinical examination, total antioxidant capacity and adenosine deaminase levels were measured. Results: The adenosine deaminase (ADA) activity in the patients at base line was high (p<0.001) than controls. The total antioxidant capacity (TAC) was low (p<0.001) in the lung fibrosis patient compared to controls. Conclusion: these findings demonstrate the adenosine signalling with chronic adenosine elevations was associated with pulmonary fibrosis in lung disease patient with decreased total antioxidant capacity.
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Sime, P.J., and K.M. O’Reily.2001 . Fibrosis of the lung amd other tissues : new concepts in pathogenesis and treatment. Clin. Immunol.99: 308-319
Lewis, M.j., E.H. Lewis, 3rd, J.A.Amos ,and G.J.Tsongalis. 2003. Cystic fibrosis. Am. J. Clin. Pathol. 120(suppl.): S3-S13.
Elias, J. A., C. G. Lee, T.Zheng, B. Ma, R. J. Homer, and Z. Zhu. 2003. New Insights into the pathogenesis of asthma. J. Clin. Invest. 111: 291-297.
Cristalli, G.; Costanzi, S.; Lambertucci, C.; Lupidi, G.; Vittori, S.; Volpini, R.; Camaioni, E.(2001). “Adenosine deaminase: Functional implications and different classes of inhibitors”. Medicinal Research Reviews 21 (2): 105-128
Hasko, G., and B. N. Cronstein. 2004. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 25: 33-39.
Is there any relationship between plasmaantioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Irfan Rahman, Elzbieta Swaeska< Michael Henry, Jan Stolk, William MacNee Thorax2000;55: 189-193.
Halliwell B, Gutteridge J M C (2000) Free radical in biology and medicine, Clarendon Press:oxford, p. 160.
Fang YZ (2002) Theory and Application of Free Radical Biology, Scientific press:Beijing, p.647.
Iris F.F. Benzic and J.J. Strain. The Ferric Reducing Ability of plasma(FRAP) as a measure of “Antioxidant Power”. The FRAP assay Article No. 0292 Analytical Biochem. 239: 1996: 70-76.
The quantitative determination of adenosine deaminase by method of Giuseppe giusti and Bruno gallant.Bergmeger H.V. Ed Methods of enzymatic analysis N.Y. Academic Press Inc.197 :308-323.
Hasko, G., and B. N. Cronstein. 2004. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 25: 33-39.
Svistunenko D A, Davies N A, Wilson M T, Stidwill R P and Singer M 19974-13. Linden, J.2001. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu. Rev. Pharmacol. Toxicol. 41: 775-787.
Tilley, S. L., V.A. Wagoner, C.A.Salvatore, M.A. Jacobson, and B. H. Koller. 2000. Adenosine and inosine increase cutaneous vasopermeability by activation A3 receptors on mast cells. J.Clin. Invest. 105:361-367
Kasahara Y, Tuder R, Taraseviciene_Stewart L,et al.Inhibition of VEGF receptors cause as lung cell apoptosis and emphysema. J Clin invest 2000; 106: 1311-1319.
Kasahara T, Matsushima K. Endothelial cell death and decreased expression of vascular growth factor and vascular endothelial growth factor receptor 2 in emphysema. Trends Immunol 2001 ; 22:593-594.
3. Joppa P, Petrasova D, Stancak B, Dorkova Z, Tkacova R. Oxidative stress in patients with COPD and pulmonary hypertension. Wien Kklin Wochenschr 2007; 119:428-34.
Kluchova Z, Petrasova D, Joppa P, Dorkava Z, Tkacova R. The association between oxidative stress and obstructive lung impairment in patients with COPD. Physiol Res 2007 ; 56:51-6.
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