Airway Antioxidant Capacity In Adenosine-Signalling Pulmonary Fibrosis In Lung Disease Patient
Keywords:
Adenosine deaminase, Lung fibrosis, Total antioxidant capacity, adenosine receptorAbstract
Background: Pulmonary fibrosis is a common feature of numerous lung disorders, including interstitial lung diseases, asthma and chronic obstructive pulmonary disease. Adenosine is a purine signalling nucleoside that is generated in excess during cellular stress and damage. Objective: the goal of this study was to explore the impact of endogenous adenosine elevations on pulmonary fibrosis and to compare ADA activity with total antioxidant capacity in lung disease patients. Methodology: in the present study 100 healthy non smokers were served as controls and 60 patients with lung fibrosis were included. Their base line clinical examination, total antioxidant capacity and adenosine deaminase levels were measured. Results: The adenosine deaminase (ADA) activity in the patients at base line was high (p<0.001) than controls. The total antioxidant capacity (TAC) was low (p<0.001) in the lung fibrosis patient compared to controls. Conclusion: these findings demonstrate the adenosine signalling with chronic adenosine elevations was associated with pulmonary fibrosis in lung disease patient with decreased total antioxidant capacity.
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