Carcinoma of Breast with Neuroendocrine Differentiation: A rare challenging entity

Authors

  • Dr. Neha Rajput DVVPFs Medical College and Hospital, Ahilyanagar-414111, Maharashtra
  • Dr. S. C. Puranik
  • Dr. S. H. Khaparde

DOI:

https://doi.org/10.46858/vimshsj.110307

Keywords:

Neuroendocrine differentiation, Breast carcinoma, Neuroendocrine tumors

Abstract

Neuroendocrine breast carcinoma (NEBC), another name for breast carcinoma with neuroendocrine differentiation, is a heterogeneous collection of uncommon tumors that make about 2-5% of all invasive breast carcinomas. Neuroendocrine tumors (NETs) originate in neuroendocrine cells. These cells combine the characteristics of endocrine cells, which produce hormones, and nerve cells. We report a rare case of carcinoma of breast with neuroendocrine differentiation. On microscopy the section of breast tumour specimen showed infiltrating duct carcinoma with area of 50% neuroendocrine differentiation.

Downloads

Download data is not yet available.

References

Vamsi Parimi, Rajen Goyal, Kate Poropatich, Ximing J Yang Am J Clin Exp Urol. 2014; 2(4): 273–285. Published online 2014 Dec 9.

Epstein JI, Amin MB, Beltran H, et al. Proposed morphologic classification of prostate cancer with neuroendocrine differentiation. Am J SurgPathol 2014;38:756–67.

Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO classification of tumours of the breast, vol. 4. 4th ed. Lyon: International Agency for Research on Cancer; 2012.

Aggarwal, G, Singh, S, Kataria, SP, Kalra, R, Duhan, A, and Sen, R. Primary Neuroendocrine Carcinoma of Breast. J Cytol (2011) 28(2):91–2.

Wang J, Wei B, Albarracin CT, et al. Invasive neuroendocrine carcinoma of the breast: a population-based study from the sur- veillance, epidemiology and end results (SEER) database. BMC Cancer. 2014;14:147-56.

Miremadi A, Pinder SE, Lee AH, et al. Neuroendocrine differentiation and prognosis in breast adenocarcinoma. Histopathology. 2002:40:215-22.

Makretsov N, Gilks CB, Coldman AJ, et al. Tissue microarray analysis of neuroendocrine differentiation and its prognostic significance in breast cancer. Hum Pathol. 2003:34:1001-8.

Van Krimpen C, Elferink A, Broodman CA, et al. The prognostic influence of neuroendocrine differentiation in breast cancer: results of a long-term follow-up study.Breast. 2004;13(4):329-33.

Rovera F, Masciocchi P, Coglitore A, et al. Neuroendocrine carcinomas of the breast. Int J Surg. 2008;6(Suppl. 1):S113-S11515.

Righi L, Sapino A, Marchio C, et al. Neuroendocrine differentia- tion in breast cancer: established facts and unresolved problems. Semin Diagn Pathol. 2010;27(1):69-766.

Published

2025-01-06

How to Cite

Rajput, D. N., Puranik, D. S. C., & Khaparde, D. S. H. . (2025). Carcinoma of Breast with Neuroendocrine Differentiation: A rare challenging entity. VIMS Health Science Journal, 11(3), 34–36. https://doi.org/10.46858/vimshsj.110307

Issue

Section

Case Report

Most read articles by the same author(s)