Evaluation of Nephroprotective Activity of Cod Liver Oil In Drug Induced Nephrotoxicity

Abstract

Cisplatin (a platinum-compound) is a anti-neoplastic drug used in the treatment of various cancers but eventually results in severe adverse effects namely nephrotoxicity or renal disorder through generation of reactive oxygen species (ROS). The existing drugs can cure most of the diseases. Still there is a never ending search for finding new drugs in the hope that it would yield drugs with lesser side effects and better therapeutic benefit than the existing drugs. This work was researched for evaluation of the Nephroprotective activity of Cod liver oil against cisplatin induced nephrotoxicity. The cod liver oil administered orally (0.5, 1, 2 gm/kg/day) for 14 day, cisplatin was administered at the dose of 7 mg/kg for 1st day intraperitoneally. Cisplatin treated group showed increased level of Serum & Urine creatinine, uric acid, urea, which were significantly retrieved in group pre-treated with cod liver oil. In conclusion the histopathological & biochemical parameter confirmed that the cod liver oil protect against cisplatin induced renal damage, probably through its antioxidant activity.