Evaluation of Efficacy of Montelukast In Rheumatoid Arthritis
Keywords:
Montelukast, Rheumatoid arthritis, CFA (Complete Freund’a adjuvant)Abstract
Rheumatoid arthritis (RA) is an autoimmune disorder. It is chronic progressive disease resulting in inflammation and deformities of joints. Being an autoimmune disease, there is lacuna in proper management of the disease. Current options like steroids and DMARD’s (disease modifying anti-rheumatic drugs) are the cornerstone in therapy of the disease, but have their own limitations. This study proves efficacy of montelukast in restricting progression of RA. Montelukast is an antagonist of leukotriene receptor. Arthritis was induced by two methods according to model by intradermal injection of Complete Freund’s Adjuvant and methylated BSA in right hind paw. Macroscopic, inflammatory biometer, X-ray and radiodiagnosis parameters were studied for both models. Hence results of this study clearly indicate that montelukast has promising anti rheumatic activity.
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