Correlation between D-dimer and HRCT in Covid-19

Dr. Dhananjay Patel; Dr. Sushil Kachewar

doi:10.46858/vimshsj.9301

Authors

Dr. Dhananjay Patel DVVPF’s Medical College & Hospital, Ahmednagar-414111, Maharashtra, India
Dr. Sushil Kachewar

DOI:

https://doi.org/10.46858/vimshsj.9301

Keywords:

Covid-19, CT severity score, D-dimer, HRCT Thorax

Abstract

Background: To retrospectively determine the correlation between CT severity score & D-dimer. Methodology: This is a retrospective original research of 227 patients (IPD & OPD) during April 1 to May 31, 2021 for Covid-19. Patients CT severity scores, HRCT Thorax findings, D-dimer, Platelet count and Demographic variables were recorded. The correlation between CT severity score & D-dimer were determined. Results: Between the mentioned dates, 227 patients are taken into study which includes 146 Males & 81 Females. Mean of CT severity score was 6.7, D-dimer was 0.46mg/l. Higher CT score is seen in males (mean -7.1) as compare to females (mean -6.12).D-dimer are seen higher in males (mean =0.52mg/l) as compare to females (median=0.37mg/l). The study of 227 patients has shown positive correlation between CT score & D-dimer (r=0.38, p<0.05). Males showed relatively stronger positive correlation(r=0.4, p<0 .05) than females(r=0.3, p<0.05).Patients with age less than equal to 45 has shown relatively stronger positive correlation between CT score & D-dimer (r=0.4, p<0.05) than patients with age more than 45 (r=0.35, p<0.05). Conclusion: Pulmonary lesion induced by SARS-CoV-2 infection was associated with raised inflammatory response, impairment in exchange of gases, and end organ damage. In study, we can conclude that lung lesion may exert important role in COVID-19 pathogenesis & clinical presentation.

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