A comparative Study of Troponin T as an Innovative Biomarker with Gold Standard Parameters In Acute Myocardial Infarction
Keywords:
Acute Myocardial Infarction, AMI, Troponin T, CK, CK-MBAbstract
Background: Myocardial infarction (MI) is the leading cause of the death in the developed world. The biomarkers have an essential role in the diagnosis, guiding management and clinical decision making in the setting of patients presenting with signs and symptoms of MI. Aim: the goal of study was to scrutinize collision of all the baseline parameters, serum troponin T as an innovative biomarker in comparison with CK & CK-MB in acute MI patients. Objectives: the intention of study was to inspect impact of serum Troponin T, CK, CK-MB along with lipid profile as baseline parameters in patients with acute MI and compared with the healthy controls. Study Design: In present case control study, 45 MI patients were estimated and compared with 45 control subjects. The concentration of cTnT was measured by immunoassay method. Estimation of serum CK-MB & CK by liquid stable optimized UV method/ immune-inhibition method. Result: a significant elevation were found in the levels of serum troponin T, CK, Ck-MB (p<0.001) in study group patients when compared with healthy controls. The cardiac troponin T has been shown to be highly sensitive for cardiac injury and not elevated in any other trauma or skeletal muscle injury. Cardiac troponin T is ordinarily undetectable in healthy individuals, and hence its measurement can serve as innovative tool in diagnosis of acute MI.
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