A comparative Study of Troponin T as an Innovative Biomarker with Gold Standard Parameters In Acute Myocardial Infarction
Keywords:
Acute Myocardial Infarction, AMI, Troponin T, CK, CK-MBAbstract
Background: Myocardial infarction (MI) is the leading cause of the death in the developed world. The biomarkers have an essential role in the diagnosis, guiding management and clinical decision making in the setting of patients presenting with signs and symptoms of MI. Aim: the goal of study was to scrutinize collision of all the baseline parameters, serum troponin T as an innovative biomarker in comparison with CK & CK-MB in acute MI patients. Objectives: the intention of study was to inspect impact of serum Troponin T, CK, CK-MB along with lipid profile as baseline parameters in patients with acute MI and compared with the healthy controls. Study Design: In present case control study, 45 MI patients were estimated and compared with 45 control subjects. The concentration of cTnT was measured by immunoassay method. Estimation of serum CK-MB & CK by liquid stable optimized UV method/ immune-inhibition method. Result: a significant elevation were found in the levels of serum troponin T, CK, Ck-MB (p<0.001) in study group patients when compared with healthy controls. The cardiac troponin T has been shown to be highly sensitive for cardiac injury and not elevated in any other trauma or skeletal muscle injury. Cardiac troponin T is ordinarily undetectable in healthy individuals, and hence its measurement can serve as innovative tool in diagnosis of acute MI.
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References
Changing of patterns in clinical care of patients with acute myocardial infraction. Braun Wald: Heart Disease: A Textbook of Cardiovascular medicine, 6th edition; pp – 1114.
Daniel Chan, Leong L Ng. Biomarkers in acute myocardial infraction. BMC Medicine 2010; 8:34.
Vishwanath Mohan, Raj Deepa, Subramaniam Santhi rani, Gopal prematha. Prevalence of coronary artery diseases and its relationship to lipid to in a selected population in south India. JACC 2001;38(3):682-687
Rajeev Bhardwaj, Arvind Kandoria, Rajeev Marwah, Piyush Vaidya. Coronary Heart Disease in Rural Population of Himachal – A Population Based Study. JAPI2009;26:67-68
Werns SW, Walton JA, Hsai HH. Evidence of endothelial dysfunction in angiographically normal coronary arteries with coronary artery disease. Circulation 1982; 79:287-291.
Ross R. The pathogenesis of atherosclerosis: An update N Engl J Med 1986; 314:488-500.
P Nigam. Biochemical markers of myocardical injury. Indian J of Clin Biochemical 2007; 22:10-17.
Christenson RH, Azzazy HM.Biochemical markers of the acute coronary syndromes. Clin Chem 1998; 44:1855-1864.
Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infraction redefined – a consensus document of the joint European Society of cardiology. Am J Coll Cardial 2000; 36(3):959-969.
Herbert K, Lipids in Clinical Chemistry; theory Analysis and co-relation, Kaplan LA and Pesce AJ, CV Mosby 1994;1182-1230.
Nader R, Paul B, John A. Lipids, Lipoproteins and Apolipoproteins. Tietz TB of Clinical Biochemistry, 3rd ed, Burtis CA and ASHWOOD er, Eds WB Saunders, Philanders, 1994; pp 809-852.
Memari Behnoush .Improved estimation of postmortem interval with Cardiac Troponin T and improved analytical methods; Analytical Biochemistry 2008: pp-177.
Young DS. Effect of drug of on clinical laboratory test. 4th ed. Washington DS; ACCC press; 1995.
Ifcc. Methods for the measurement of catalytic concentration of enzymes, JIFCC. 1989; 1:130.
Hebert K, lipids in Clinical Chemistry; theory, Analysis and co –relation, Kaplan LA and Pesce AJ, CV Mosby 1984;1182-1230.
Eric Christenson M.D 1 and Robert H. Christenson, Ph.D. The Role of cardiac Biomarkers in the Diagnosis and Management of Patients Presenting with Suspected Acute Coronary Syndrome Analysis of laboratory Medicine 2013; 33:309-318.
Hitesh Shah and N. Haridas. Evaluation of clinical utility of serum enzymes and troponin –T in the early stage of acute myocardial infraction. Indian J of Clin Biochem 2003;18(2):93-101
Eisenberg E, Kielley WW. Troponin- tropomysin complex. J Biol Chem 1974; 18(2):93-101.
Thygesen K. all third universal definition of myocardial infraction Circulation 2012; 126:2020-2035.
Tomasz R, a RTuR DzziewieRz, Jacek LT, Pawel Kleczynski et al Creatie Kinase – MB assessed in patients with acute myocardial infraction correlates with cardiac magnetic resonance infarct size at 6- month follow up. Hellenic J Cardiol 2014; 55:4-8
YF Choi TW Wong, CC Lau. The diagnostic value and cost- effectiveness of creatine kinase- MB myoglobin and cardiac troponin – T for patients with chest pain emergency department observation ward. Hong Cong j of Emergency Medicine 2004; 11 (2): 85-90.
C.M Nagesh and AMBUJ Roy. Role biomarkesrts in risk stratification of acute coronary syndrome. Indian J Med Res 2010; 312:627-633.
Ooi DS Isotalo PA, Veinot JP. Correlation of antemortem serum creatin kinase, creatine kinase- MB, troponin T with cardiac pathology. Clin Chem 2000; 46:338-344.
Johannes M. E rika Ather- Dworzac Peter L et al. cardiac troponin T.in diagnosis of acute myocardial infraction. Clin. Chem 1991:37:845-852.
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