Diagnostic Importance of Creatine Kinase MB - Isoenzyme in Chronic Hemodialysis Patients.
Keywords:
Chronic renal failure (CRF), Creatinine kinase MB (CK - MB), Cardiac BiomarkersAbstract
Chronic renal failure (CRF) results from advanced and irrevocable destruction of nephrons, despite of the cause. Chronic renal failure patients are having higher risk of cardiac problems. The present study was considered to evaluate use of serum cardiac marker in chronic renal failure. Total 89 patients were studied in between age group 40 to 70 years. After applying the inclusion and exclusion criteria, a total of 60 chronic renal failure patients were eligible for the study. The data was collected and compared with 60 age and sex matched healthy controls from the same age group. The statistical analysis was done using SPSS 16.0 software. All the patients were assessedwith creatinine kinase MB (CK-MB) and baseline parameters such as RBS (random blood sugar), blood urea, creatinine and total cholesterol.
The concentrations of CK-MB, RBS, blood urea, creatinine, and total cholesterol were significantly elevated (P<0.001) when compared with control group. Patients maintained on chronic dialysis without evidence of acute myocardial injury often have chronically increased CK-MB concentration.
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