The relationship between psoriasis and leprosy is debatable since ages. The varied clinical manifestations of leprosy may resemble other skin diseases, but there is no documented literature of skin lesions of psoriasis mimicking leprosy. We report a case of generalised pustular psoriasis (GPP) presented with the lepromatous leprosy like clinical features in a 60 year old male. The histopathological examination confirmed the diagnosis. Patient was then treated with Methotrexate 7.5mg weekly and showed improvement in subsequent visits. We report this rare possibility to raise awareness among clinicians to allow accurate diagnosis since leprosy still carries stigma in society.
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