Neonatal Cerebral Sinovenous Thrombosis: A Case Report

Authors

  • Dr. Snehal S. Jagtap Department of Paediatrics, DVVPFs Medical College & Hospital, Ahmednagar-414111, Maharashtra, India
  • Dr. Abhijit Shinde
  • Prof. Dr. Sunil Natha Mhaske
  • Dr. Suresh Waydande
  • Dr. Sushrut Kumar

DOI:

https://doi.org/10.46858/vimshsj.10205

Keywords:

Cerebral Sinovenous Thrombosis, Stroke, Infarction, Convulsion, Neuroimaging

Abstract

Neonatal cerebral sino-venous thrombosis (CSVT) is a rare disorder, associated with long-term neurological sequelae. Cerebral sino-venous thrombosis (CSVT) is a focal or diffuse disruption of cerebral blood flow secondary to occlusion of cerebral veins and/or sinuses. The most commonly presented clinical manifestations were feeding difficulties, lethargy, respiratory distress, loss of consciousness, and seizures. Here we report one such rare case of Neonatal Cerebral Sinovenous Thrombosis in a full-term male admitted to the NICU in view of respiratory distress due to meconium-stained liquor and cried immediately after birth. The baby had convulsions on day 5 of life, MRI Brain was done and reported as multifocal areas of diffusion on restriction and large areas of diffusion restriction involving various parts of brain. Subcutaneous low molecular heparin was started. There is limited literature describing outcomes: 60?80% of all infants have some neurological deficits; cognitive impairment is reported in 10?60%, and epilepsy in 30?40%.

Downloads

Download data is not yet available.

References

deVeber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ, Camfield CS, David M, Humphreys P, Langevin P, MacDonald EA. Cerebral sinovenous thrombosis in children. New England Journal of Medicine. 2001 Aug 9;345(6):417-23.

Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics. 1995 Nov;96(5):939-43.

Monagle P, Barnes C, Ignjatovic V, Furmedge J, Newall F, Chan A, De Rosa L, Hamilton S, Ragg P, Robinson S, Auldist A. Developmental haemostasis. Thrombosis and haemostasis. 2006;95(02):362-72.

Ramenghi LA, Cardiello V, Rossi A. Neonatal cerebral sinovenous thrombosis. Handbook of clinical neurology. 2019 Jan 1;162:267-80.

Kouzmitcheva E, Moharir M. Neonatal cerebral sinovenous thrombosis: the anticoagulation debate. Developmental medicine and child neurology. 2018 Apr 19;60(9):853.

Moharir MD, Shroff M, Stephens D, Pontigon AM, Chan A, MacGregor D, Mikulis D, Adams M, deVeber G. Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Annals of neurology. 2010 May;67(5):590-9.

Kersbergen KJ, de Vries LS, Van Straaten HL, Benders MJ, Nievelstein RA, Groenendaal F. Anticoagulation therapy and imaging in neonates with a unilateral thalamic hemorrhage due to cerebral sinovenous thrombosis. Stroke. 2009 Aug 1;40(8):2754-60.

Ramenghi LA, Govaert P, Fumagalli M, Bassi L, Mosca F. Neonatal cerebral sinovenous thrombosis. InSeminars in Fetal and Neonatal Medicine 2009 Oct 1 (Vol. 14, No. 5, pp. 278-283). WB Saunders.

Van der Aa NE, Benders MJ, Groenendaal F, De Vries LS. Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options. Acta paediatrica. 2014 Apr;103(4):356-64.

Fitzgerald KC, Golomb MR. Neonatal arterial ischemic stroke and sinovenous thrombosis associated with meningitis. Journal of child neurology. 2007 Jul;22(7):818-22.

Fitzgerald KC, Williams LS, Garg BP, Carvalho KS, Golomb MR. Cerebral sinovenous thrombosis in the neonate. Archives of neurology. 2006 Mar 1;63(3):405-9.

Wu YW, Miller SP, Chin K, Collins AE, Lomeli SC, Chuang NA, Barkovich AJ, Ferriero DM. Multiple risk factors in neonatal sinovenous thrombosis. Neurology. 2002 Aug 13;59(3):438-40.

Claessens NH, Algra SO, Jansen NJ, Groenendaal F, de Wit E, Wilbrink AA, Haas F, Schouten AN, Nievelstein RA, Benders MJ, de Vries LS. Clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery. The Journal of thoracic and cardiovascular surgery. 2018 Mar 1;155(3):1150-8.

Kersbergen KJ, de Vries LS, Van Straaten HL, Benders MJ, Nievelstein RA, Groenendaal F. Anticoagulation therapy and imaging in neonates with a unilateral thalamic hemorrhage due to cerebral sinovenous thrombosis. Stroke. 2009 Aug 1;40(8):2754-60.

Downloads

Published

2023-06-30

How to Cite

Jagtap, D. S. S., Shinde, D. A. ., Mhaske, P. D. S. N. ., Waydande, D. S. ., & Kumar, D. S. (2023). Neonatal Cerebral Sinovenous Thrombosis: A Case Report. VIMS Health Science Journal, 10(2), 54–57. https://doi.org/10.46858/vimshsj.10205

Issue

Section

Case Report

Most read articles by the same author(s)

<< < 1 2 3 > >>